Humans have extended and improved our lives through highly sophisticated and expensive mechanical organs created by a company called The Union. The dark side of these medical breakthroughs is that if you don't pay your bill, The Union sends its highly skilled repo men to take back its property, with no concern for your comfort or survival.

In the not-so-distant future, a worldwide epidemic of organ failures devastates the planet. Out of the tragedy, a savior emerges called GENECO, a biotech company that offer organ transplants, but at a steep price. Those who miss their payments are scheduled for repossession and are hunted by the Repo Man.

Bob's happy marriage is shattered when his wife, Elizabeth, suddenly dies in a tragic accident. At the time, Grace begins to rebuild her life after receiving a heart transplant. Through fate, their lives constantly intertwine.